The ability of pollen to enable the glaciation of supercooled liquid water has been demonstrated in laboratory studies; however, the potential large-scale effect of trees and pollen on clouds, precipitation and climate is pressing knowledge to better understand and project clouds in the current and future climate. Combining ground-based measurements of pollen concentrations and satellite observations of cloud properties within the United States, we show that enhanced pollen concentrations during springtime lead to a higher cloud ice fraction. We further establish the link from the pollen-induced increase in cloud ice to a higher precipitation frequency. In light of anthropogenic climate change, the extended and strengthened pollen season and future alterations in biodiversity can introduce a localized climate forcing and a modification of the precipitation frequency and intensity.